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Original scientific article

AN EARLY DETECTION OF KAWASAKI DISEASE USING ENHANCED FEATURE SELECTION AND HYBRIDIZATION-BASED CLASSIFICATION APPROACH

By
C. Kavitha Orcid logo ,
C. Kavitha

Mother Teresa Women’s University , Dindigul , India

A. Subramani Orcid logo
A. Subramani

M.V. Muthiah Govt. Arts College for Women , Dindigul , India

Abstract

Kawasaki disease (KD) is a disease that cause inflammation in blood vessels, impacting kids and causes heart and blood vessel damage. Patients with KD who have medium or big aneurysms, developing coronary dilatation for a minimum of 2 months, are related to the worst late coronary results, which are not widely researched. The primary goal of the suggested technique is to introduce an intelligent framework that can perform clinical data mining more accurately. In this, clinical data mining is done by using the novel hybridized classification approach. Initially, to replace the missing data, the Random Forest (RF) algorithm is proposed. Then, using the optimization algorithm, the feature selection is done, namely the artificial bee colony approach, which would select the best feature from the training data set. F-score values are considered as the fitness values for optimal feature selection. Finally, the classification process is done using the proposed hybridization approach; clustering is done before classification and in every iteration of classification. The clustering is done using the FCM clustering, and Deep neural network is employed for classification. The simulation results identified that the proposed hybridization approach has better classification accuracy, leading to an efficient assessment of KD.

References

1.
Makino N, Nakamura Y, Yashiro M, Kosami K, Matsubara Y, Ae R. Nationwide epidemiologic survey of Kawasaki disease in Japan. Pediatrics International. 2015;(4):397–403.
2.
Kato H. Cardiovascular complications in Kawasaki disease: coronary artery lumen and long-term consequences. Progress in Pediatric Cardiology. 2004;19(2):137–45.
3.
Benseler SM, McCrindle BW, Silverman ED, Tyrrell PN, Wong J, Yeung RSM. Infections and Kawasaki Disease: Implications for Coronary Artery Outcome. Pediatrics. 2005;116(6):e760–6.
4.
Honkanen VEA, McCrindle BW, Laxer RM, Feldman BM, Schneider R, Silverman ED. Clinical Relevance of the Risk Factors for Coronary Artery Inflammation in Kawasaki Disease. Pediatric Cardiology. 2003;24(2):122–6.
5.
Cimaz R, Sundel R. Atypical and incomplete Kawasaki disease. Best Practice & Research Clinical Rheumatology. 2009;23(5):689–97.
6.
SONOBE T, KIYOSAWA N, TSUCHIYA K, ASO S, IMADA Y, IMAI Y, et al. Prevalence of coronary artery abnormality in incomplete Kawasaki disease. Pediatrics International. 2007;49(4):421–6.
7.
Dajani AS, Taubert KA, Gerber MA, Shulman ST, Ferrieri P, Freed M, et al. Diagnosis and therapy of Kawasaki disease in children. Circulation. 1993;87(5):1776–80.
8.
McCrindle BW, Li JS, Minich LL, Colan SD, Atz AM, Takahashi M, et al. Coronary Artery Involvement in Children With Kawasaki Disease. Circulation. 2007;116(2):174–9.
9.
Takeuchi M, Inuzuka R, Hayashi T, Shindo T, Hirata Y, Shimizu N, et al. Novel Risk Assessment Tool for Immunoglobulin Resistance in Kawasaki Disease. Pediatric Infectious Disease Journal. 2017;36(9):821–6.
10.
Zandstra J, van de Geer A, Tanck MWT, van Stijn-Bringas Dimitriades D, Aarts CEM, Dietz SM, et al. Biomarkers for the Discrimination of Acute Kawasaki Disease From Infections in Childhood. Frontiers in Pediatrics. 2020;8.
11.
Bozlu G, Karpuz D, Hallioglu O, Unal S, Kuyucu N. Relationship between mean platelet volume-to-lymphocyte ratio and coronary artery abnormalities in Kawasaki disease. Cardiology in the Young. 2018;28(6):832–6.
12.
Tremoulet AH, Dutkowski J, Sato Y, Kanegaye JT, Ling XB, et al. Novel data-mining approach identifies biomarkers for diagnosis of Kawasaki disease. Pediatric Research. 2015;78(5):547–53.
13.
Sosa T, Brower L, Divanovic A. Diagnosis and Management of Kawasaki Disease. JAMA Pediatrics. 2019;173(3):278.
14.
Burns JC, DeHaan LL, Shimizu C, Bainto EV, Tremoulet AH, Cayan DR, et al. Temporal Clusters of Kawasaki Disease Cases Share Distinct Phenotypes That Suggest Response to Diverse Triggers. The Journal of Pediatrics. 2021;229:48-53.e1.
15.
Pezoulas VC, Papaloukas C, Veyssiere M, Goules A, Tzioufas AG, Soumelis V, et al. A computational workflow for the detection of candidate diagnostic biomarkers of Kawasaki disease using time-series gene expression data. Computational and Structural Biotechnology Journal. 2021;19:3058–68.
16.
Kuniyoshi Y, Tokutake H, Takahashi N, Kamura A, Yasuda S, Tashiro M. Comparison of Machine Learning Models for Prediction of Initial Intravenous Immunoglobulin Resistance in Children With Kawasaki Disease. Frontiers in Pediatrics. 2020;8.
17.
Malhotra A, Joshi S. Exploring the Intersection of Demographic Change and Healthcare Utilization: An Examination of Age-Specific Healthcare Needs and Service Provision. Progression Journal of Human Demography and Anthropology. 2025;8–14.
18.
Ling XB, Lau K, Kanegaye JT, Pan Z, Peng S, Ji J, et al. A diagnostic algorithm combining clinical and molecular data distinguishes Kawasaki disease from other febrile illnesses. BMC Medicine. 2011;9(1).
19.
Asha S, Pai P, Kamath P, Madli R, Arjunan R. An Improved EEG Signal Feature Selection Paradigm for Migraine Detection. Journal of Internet Services and Information Security. 2024;(3):143–56.
20.
Chu F, He XQ, Yue Y, Jie T, Sheng Z, Zhe L. BP neural network model for the differentiation of Kawasaki disease and febrile illnesses based on data mining. Chinese Journal of Evidence-Based Pediatrics. 2017;(1):22.
21.
Pillai D, Bhatia S. Ontology-Driven Approaches for Standardizing Rare Disease Terminology. Global Journal of Medical Terminology Research and Informatics. 2024;(2):5–9.
22.
Wang H, Tan X, Huang Z, Pan B, Tian J. Mining incomplete clinical data for the early assessment of Kawasaki disease based on feature clustering and convolutional neural networks. Artificial Intelligence in Medicine. 2020;105:101859.
23.
Shrivastav P, Malakar U. Exploring Barriers to Medication Adherence Among Patients with Chronic Diseases. Clinical Journal for Medicine, Health and Pharmacy. 2024;(3):21–31.
24.
Palanisamy S, Kanmani S. Artificial bee colony approach for optimizing feature selection. International Journal of Computer Science Issues. 2012;(3):432.
25.
Bhatia M, Iyer R, R. Immunological Responses to Viral Infections. Medxplore: Frontiers in Medical Science Periodic Series in Multidisciplinary Studies. :52–70.
26.
Kim P. Convolutional Neural Network. MATLAB Deep Learning. Apress; 2017. p. 121–47.
27.
Manlhiot C, Mueller B, O’Shea S, Majeed H, Bernknopf B, Labelle M, et al. Environmental epidemiology of Kawasaki disease: Linking disease etiology, pathogenesis and global distribution. PLOS ONE. 2018;13(2):e0191087.
28.
Liu MY, Liu HM, Wu CH, Chang CH, Huang GJ, Chen CA, et al. Risk factors and implications of progressive coronary dilatation in children with Kawasaki disease. BMC Pediatrics. 2017;17(1).
29.
Szymanski A, Clifford H, Ronis T. Fever of unknown origin: a retrospective review of pediatric patients from an urban, tertiary care center. World J Pediatr. 2020;(2):177–84.
30.
Tang F, Ishwaran H. Random Forest missing data algorithms. Statistical Analysis and Data Mining: The ASA. Data Science Journal. (2):363–77.
31.
Cannon RL, Dave JV, Bezdek JC. Efficient Implementation of the Fuzzy c-Means Clustering Algorithms. IEEE Transactions on Pattern Analysis and Machine Intelligence. 1986;PAMI-8(2):248–55.
32.
Miriyala GP, Sinha AK. Precision Diagnosis of Coronary Artery Disease with  OTLGBM. Journal of Wireless Mobile Networks, Ubiquitous Computing, and Dependable Applications. 2025;16(1):230–46.

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