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Original scientific article

A NOVEL DEEP CONVOLUTIONAL RECURRENT STATE SPACE MODEL FOR ROBUST ADVERSE DRUG REACTION IDENTIFICATION USING DT FEATURE SELECTION AND BOW ENCODING

By
R. Deepalakshmi Orcid logo ,
R. Deepalakshmi
Contact R. Deepalakshmi

Department of Computer Science and Engineering, Jain Deemed to be University, Bengaluru, Karnataka, India

Dr. Manikandan Parasuraman Orcid logo ,
Dr. Manikandan Parasuraman

Department of Computer Science and Engineering, Jain Deemed-to-be-University, Bengaluru, Karnataka, India

Dr.V. Manikandan Orcid logo
Dr.V. Manikandan

Department of Computer Science and Engineering, Jain Deemed-to-be-University, Bengaluru, Karnataka, India

Abstract

Social Media Detection of Adverse Drug Reactions (ADRs) has evolved as an important technique for today's pharmacovigilance. Real-time detection through social media platforms such as Twitter has been proven effective but has been hindered by issues related to linguistic noise, syntactic variations, and imbalanced data. In this paper, a new Deep Convolutional Recurrent State Space Model (DCR-SSM) coupled with a decision tree (DT) and a bag of words (BoW) is presented. Domain-specific normalization and filtering of noise will be conducted to improve data quality. Feature engineering techniques include high-impact feature selection using the Decision Tree approach with information gain and BoW encoding of features in numeric vector format. DCR-SSM is designed to exploit the benefits of the convolution operation for feature extraction, recurrent neural networks with Bi-LSTM/GRU layers for sequence processing, and State Space Models (SSM) for managing long-distance dependencies. The experimental tests carried out using the SMM4H and TwiMed datasets prove that the architecture is superior, registering an accuracy score of 93.81%, a precision rate of 91.33%, a recall score of 96.80%, and an F1 score of 93.99%. In addition, the architecture scored a commendable ROC-AUC score of 97.90%. The results confirm that the architecture performs effectively when handling complex social media datasets.

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Citation

This is an open access article distributed under the  Creative Commons Attribution Non-Commercial License (CC BY-NC) License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 

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Issue 36, 2026
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