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Review paper

HEALTHCARE DATA EXCHANGE IN THE ERA OF BLOCKCHAIN AND AI: A SURVEY ON METHODS, CHALLENGES, AND ARCHITECTURES

By
K. Deepthika Orcid logo ,
K. Deepthika

Government College of Engineering India

Dr. I. Bhuvaneshwarri Orcid logo
Dr. I. Bhuvaneshwarri

Government College of Engineering India

Abstract

Background: Interoperability, privacy, and the background of healthcare information are significant issues in the healthcare industry, mainly because of the fragmentation of the data. Conventional solutions are not secure, transparent, and accurate enough to share data effectively. Purpose: The purpose of the study is to examine how blockchain and Artificial Intelligence (AI) may be integrated to streamline the process of sharing healthcare data to be secure, intact, and provide superior decision-making in clinical practice. Methods: The study will be based on the use of blockchain and AI in healthcare, namely, using Smart Contracts to share electronic health records, Federated Learning to train AI models, and identity access control by AI using blockchain systems. The models have been tested on benchmark healthcare data, and parameters of the models, which include the data access latency, transactions per second, and the accuracy of prediction. Findings: The AI-blockchain hybrid architecture was shown to have a considerable enhancement in the workability of healthcare information, the stability of the system, and the correctness of choices. The prediction models based on AI worked successfully in identifying medical anomalies and analyzing various medical data. Also, blockchain provides integrity of data because of a decentralized and unalterable ledger. Conclusion: The paper identifies the possibility of blockchain and AI integration in health to implement the exchange of data. The proposed system is expected to increase security, decrease the latency, and increase the accuracy of the prediction, which is a promising solution to secure, efficient, and reliable data exchange in healthcare.

References

1.
Pandl KD, Thiebes S, Schmidt-Kraepelin M, Sunyaev A. On the convergence of artificial intelligence and distributed ledger technology: A scoping review and future research agenda. IEEE access. 2020 Mar 17;8:57075-95.
2.
Boopathy EV, Appa MAYPM, Pragadeswaran S, Raja DK, Gowtham M, Kishore R, et al. (2024). A Data Driven Approach through IOMT based Patient Healthcare Monitoring System. Archives for Technical Sciences, 2(31), 9-15.
3.
Dagher GG, Mohler J, Milojkovic M, Marella PB. Ancile: Privacy-preserving framework for access control and interoperability of electronic health records using blockchain technology. Sustainable cities and society. 2018 May 1;39:283-97.
4.
Menaka DrSR, Raj MG, Selvan PE, Kumar GT, Yashika M. (2022). A Sensor based Data Analytics for Patient Monitoring Using Data Mining. International Academic Journal of Innovative Research, 9(1), 28–36.
5.
Marwala T, Xing B. Blockchain and artificial intelligence. arXiv preprint arXiv:1802.04451. 2018 Feb 13.
6.
Krishnan H, Santhosh S, Vijay V, Yasmin S. (2022). Blockchain for Health Data Management. International Academic Journal of Science and Engineering, 9(2), 23–27.
7.
Dinh TN, Thai MT. AI and blockchain: A disruptive integration. Computer. 2018 Sep;51(9):48-53.
8.
Hamouda BE. (2025). Enhancing security and privacy in AI-enabled IoT smart healthcare devices: Practical solutions for protecting patient data. Journal of Internet Services and Information Security, 15(3), 1–17.
9.
Hu Y, Kuang W, Qin Z, Li K, Zhang J, Gao Y, et al. Artificial intelligence security: Threats and countermeasures. ACM Computing Surveys (CSUR). 2021 Nov 23;55(1):1-36.
10.
Sunitha BJ, Kumar DrSS. (2025). A novel hybrid blockchain-ABAC framework for multi-layered access control in cloud-based healthcare systems: Performance optimization and regulatory compliance. Journal of Wireless Mobile Networks, Ubiquitous Computing, and Dependable Applications, 16(3), 178–197.
11.
Abbas K, Afaq M, Ahmed Khan T, Song WC. A blockchain and machine learning-based drug supply chain management and recommendation system for smart pharmaceutical industry. Electronics. 2020 May 21;9(5):852.
12.
Ghazi A, Alisawi M, Hammood L, Abdullah SS, Al-Dawoodi A, Ali AH, et al. Data mining and machine learning techniques for coronavirus (COVID-19) pandemic: A review study. InAIP Conference Proceedings 2023 Sep 29 (Vol. 2839, No. 1, p. 040010). AIP Publishing LLC.
13.
Ganggayah M, Taib N, Har Y, Lio P, Dhillon S. Predicting factors for survival of breast cancer patients using machine learning techniques. BMC medical informatics and decision making. 2019 Mar 22;19(1):48.
14.
Gangwal A, Gangavalli HR, Thirupathi A. A survey of layer-two blockchain protocols. Journal of Network and Computer Applications. 2023 Jan 1;209:103539.
15.
Periyasamy S, Kaliyaperumal P, Thirumalaisamy M, Balusamy B, Elumalai T, Meena V, et al. Blockchain enabled collective and combined deep learning framework for COVID19 diagnosis. Scientific Reports. 2025 May 13;15(1):16527.
16.
Gao F, Wu T, Chu X, Yoon H, Xu Y, Patel B. Deep residual inception encoder–decoder network for medical imaging synthesis. IEEE journal of biomedical and health informatics. 2019 Apr 22;24(1):39-49.
17.
Giger ML, Suzuki K. InBiomedical information technology 2008 Jan 1 (pp. 359-XXII). Academic Press.
18.
Rakhmanovich IU, Ryad Hossein R, Albdairi M, Omonov Q, Kumaraswamy B. Predictive Analytics and Automation: Transforming Logistics with Artificial Intelligence with Blockchain Intelligence. In2025 International Conference on Computational Innovations and Engineering Sustainability (ICCIES) 2025 Apr 24 (pp. 1-6). IEEE.
19.
Gordon WJ, Catalini C. Blockchain technology for healthcare: facilitating the transition to patient-driven interoperability. Computational and structural biotechnology journal. 2018 Jan 1;16:224-30.
20.
Estiri H, Strasser ZH, Rashidian S, Klann JG, Wagholikar KB, McCoy TH, et al. An objective framework for evaluating unrecognized bias in medical AI models predicting COVID-19 outcomes. Journal of the American Medical Informatics Association. 2022 Aug 1;29(8):1334-41.
21.
Heidari A, Toumaj S, Navimipour NJ, Unal M. A privacy-aware method for COVID-19 detection in chest CT images using lightweight deep conventional neural network and blockchain. Computers in Biology and Medicine. 2022 Jun 1;145:105461.
22.
Das AK, Bera B, Giri D. Ai and blockchain-based cloud-assisted secure vaccine distribution and tracking in iomt-enabled covid-19 environment. IEEE Internet of Things Magazine. 2021 Jul 21;4(2):26-32.
23.
Das S, Nayak GK, Saba L, Kalra M, Suri JS, Saxena S. An artificial intelligence framework and its bias for brain tumor segmentation: A narrative review. Computers in biology and medicine. 2022 Apr 1;143:105273.
24.
El Houda A, Hafid Z, Khoukhi A, Brik L, B. When collaborative federated learning meets blockchain to preserve privacy in healthcare. IEEE Transactions on Network Science and Engineering. 2022 Sep 30;10(5):2455-65.
25.
Abugabah A, Nizamuddin N, Alzubi AA. Decentralized telemedicine framework for a smart healthcare ecosystem. Ieee Access. 2020 Sep 4;8:166575-88.
26.
Ahmed I, Chehri A, Jeon G. Artificial intelligence and blockchain enabled smart healthcare system for monitoring and detection of covid-19 in biomedical images. IEEE/ACM transactions on computational biology and bioinformatics. 2023 Jul 12;21(4):814-22.
27.
Aich S, Sinai NK, Kumar S, Ali M, Choi YR, Joo MI, et al. Protecting personal healthcare record using blockchain & federated learning technologies. In2022 24th international conference on advanced communication technology (ICACT) 2022 Feb 13 (pp. 109-112). Ieee.
28.
Alhadhrami Z, Alghfeli S, Alghfeli M, Abedlla JA, Shuaib K. Introducing blockchains for healthcare. In2017 international conference on electrical and computing technologies and applications (ICECTA) 2017 Nov 21 (pp. 1-4). IEEE.
29.
Alhazmi HE, Eassa FE, Sandokji SM. Towards big data security framework by leveraging fragmentation and blockchain technology. IEEE Access. 2022 Jan 18;10:10768-82.
30.
Ali S, Abdullah, Armand TPT, Athar A, Hussain A, Ali M, et al. Metaverse in healthcare integrated with explainable AI and blockchain: enabling immersiveness, ensuring trust, and providing patient data security. Sensors. 2023 Jan 4;23(2):565.
31.
Alrubei SM, Ball E, Rigelsford JM. The use of blockchain to support distributed AI implementation in IoT systems. IEEE Internet of Things Journal. 2021 Mar 8;9(16):14790-802.
32.
Alruwaili FF. Artificial intelligence and multi agent based distributed ledger system for better privacy and security of electronic healthcare records. PeerJ Computer Science. 2020 Nov 30;6:e323.
33.
Alruwaili FF, Alabduallah B, Alqahtani H, Salama AS, Mohammed GP, Alneil AA. Blockchain enabled smart healthcare system using jellyfish search optimization with dual-pathway deep convolutional neural network. IEEE Access. 2023 Aug 10;11:87583-91.
34.
Al-Safi H, Munilla J, Rahebi J. Patient privacy in smart cities by blockchain technology and feature selection with Harris Hawks Optimization (HHO) algorithm and machine learning. Multimedia Tools and Applications. 2022 Mar;81(6):8719-43.
35.
Alzubi JA, Alzubi OA, Singh A, Ramachandran M. Cloud-IIoT-based electronic health record privacy-preserving by CNN and blockchain-enabled federated learning. IEEE Transactions on Industrial Informatics. 2022 Jul 7;19(1):1080-7.
36.
Antal C, Cioara T, Antal M, Anghel I. Blockchain platform for COVID-19 vaccine supply management. IEEE Open Journal of the Computer Society. 2021 Mar 22;2:164-78.
37.
Baucas MJ, Spachos P, Plataniotis KN. Federated learning and blockchain-enabled fog-IoT platform for wearables in predictive healthcare. IEEE Transactions on Computational Social Systems. 2023 Jan 17;10(4):1732-41.
38.
Bhattacharya P, Tanwar S, Bodkhe U, Tyagi S, Kumar N. Bindaas: Blockchain-based deep-learning as-a-service in healthcare 4.0 applications. IEEE transactions on network science and engineering. 2019 Dec 25;8(2):1242-55.
39.
Celesti A, Ruggeri A, Fazio M, Galletta A, Villari M, Romano A. Blockchain-based healthcare workflow for tele-medical laboratory in federated hospital IoT clouds. Sensors. 2020 May 2;20(9):2590.
40.
Chen X, Ji J, Luo C, Liao W, Li P. When machine learning meets blockchain: a decentralized, privacy-preserving and secure design. In: Proceedings of the IEEE International Conference on Big Data (Big Data); 2018 Dec 10; Seattle, WA. Piscataway (NJ): IEEE; 2018. p. 1178–1187.
41.
Cheng X, Chen F, Xie D, Sun H, Huang C. Design of a secure medical data sharing scheme based on blockchain. Journal of medical systems. 2020 Feb;44(2):52.
42.
Cheng AS, Guan Q, Su Y, Zhou P, Zeng Y. Integration of machine learning and blockchain technology in the healthcare field: a literature review and implications for cancer care. Asia-Pacific journal of oncology nursing. 2021 Nov 1;8(6):720-4.
43.
Churi P, Pawar A, Moreno-Guerrero AJ. A comprehensive survey on data utility and privacy: Taking Indian healthcare system as a potential case study. Inventions. 2021 Jun 23;6(3):45.
44.
Dilmaghani S, Brust MR, Danoy G, Cassagnes N, Pecero J, Bouvry P. Privacy and security of big data in AI systems: A research and standards perspective. In2019 IEEE international conference on big data (big data) 2019 Dec 9 (pp. 5737-5743). IEEE.
45.
Dorri A, Kanhere S, Jurdak R. Blockchain in internet of things: challenges and solutions. arXiv preprint arXiv:1608.05187. 2016 Aug 18.
46.
Duan Y, Edwards JS, Dwivedi YK. Artificial intelligence for decision making in the era of Big Data–evolution, challenges and research agenda. International journal of information management. 2019 Oct 1;48:63-71.
47.
Durga R, Poovammal E. Fled-block: Federated learning ensembled deep learning blockchain model for covid-19 prediction. Frontiers in Public Health. 2022 Jun 17;10:892499.
48.
Azaria A, Ekblaw A, Vieira T, Lippman A. A case study for blockchain in healthcare: “MedRec” prototype for electronic health records and medical research data. In: Proceedings of the IEEE Open & Big Data Conference; 2016 Aug 13; Vienna, Austria. Piscataway (NJ): IEEE; 2016.
49.
El Rifai O, Biotteau M, De Boissezon X, Megdiche I, Ravat F, Teste O. Blockchain-based federated learning in medicine. InInternational conference on artificial intelligence in medicine 2020 Aug 25 (pp. 214-224). Cham: Springer International Publishing.
50.
Feng Q, He D, Zeadally S, Khan MK, Kumar N. A survey on privacy protection in blockchain system. Journal of network and computer applications. 2019 Jan 15;126:45-58.
51.
Feng L, Yang Z, Guo S, Qiu X, Li W, Yu P. Two-layered blockchain architecture for federated learning over the mobile edge network. IEEE network. 2021 Jan 8;36(1):45-51.
52.
Funk E, Riddell J, Ankel F, Cabrera D. Blockchain Technology: A Data Framework to Improve Validity, Trust, and Accountability of Information Exchange in Health Professions Education. Academic Medicine. 2018;93(12):1791–4.
53.
Guo R, Shi H, Zheng D, Jing C, Zhuang C, Wang Z. Flexible and Efficient Blockchain-Based ABE Scheme With Multi-Authority for Medical on Demand in Telemedicine System. IEEE Access. 2019;7:88012–25.
54.
Gupta R, Tanwar S, Tyagi S, Kumar N, Obaidat MS, Sadoun B. HaBiTs: Blockchain-based Telesurgery Framework for Healthcare 4.0. 2019 International Conference on Computer, Information and Telecommunication Systems (CITS). IEEE; 2019. p. 1–5.
55.
Haddad A, Habaebi M, Islam M, Hasbullah N, Zabidi S. Systematic review on ai-blockchain based ehealthcare records management systems. IEEE access. 2022;94583–615.
56.
Haddad A, Habaebi MH, Islam MdR, Hasbullah NF, Zabidi SA. Systematic Review on AI-Blockchain Based E-Healthcare Records Management Systems. IEEE Access. 2022;10:94583–615.
57.
Hao Z, Tian G, Zhang C, B. A distributed computation model based on federated learning integrates heterogeneous models and consortium blockchain for solving time-varying problems. 2023;
58.
Hasselgren A, Wan P, Horn M, Kralevska K, Gligoroski D, Faxvaag A. 2020;
59.
Hepp T, Schoenhals A, Gondek C, Gipp B. OriginStamp: A blockchain-backed system for decentralized trusted timestamping. it - Information Technology. 2018;60(5–6):273–81.
60.
Benji M, Sindhu M. A study on the Corda and Ripple blockchain platforms. InAdvances in Big Data and Cloud Computing: Proceedings of ICBDCC18. 2018;179–87.
61.
Francisco K, Swanson D. The Supply Chain Has No Clothes: Technology Adoption of Blockchain for Supply Chain Transparency. Logistics. 2018;2(1):2.
62.
Buterin V, Illum J, Nadler M, Schär F, Soleimani A. Blockchain privacy and regulatory compliance: Towards a practical equilibrium. Blockchain: Research and Applications. 2024;5(1):100176.
63.
Hamze L. Blockchain-based solution for covid-19 vaccine distribution. 2021;
64.
Bathula A, Gupta S kr., Merugu S, Skandha SS. Academic Projects on Certification Management Using Blockchain- A Review. 2022 International Conference on Recent Trends in Microelectronics, Automation, Computing and Communications Systems (ICMACC). IEEE; 2022. p. 1–6.
65.
Anita. N, Vijayalakshmi. M. Blockchain Security Attack: A Brief Survey. 2019 10th International Conference on Computing, Communication and Networking Technologies (ICCCNT). IEEE; 2019. p. 1–6.
66.
Gori M, Monfardini G, Scarselli F. A new model for learning in graph domains. Vol. 2, Proceedings. 2005 IEEE International Joint Conference on Neural Networks, 2005. IEEE; p. 729–34.
67.
Gräther W, Kolvenbach S, Ruland R, Schütte J, Torres C, Wendland F. Blockchain for education: lifelong learning passport. InProceedings of 1st ERCIM Blockchain workshop. 2018;
68.
Bose A, Sarkar DrP, Jana DrP. Data Biasing Removal with Blockchain and Crowd Annotation. Procedia Computer Science. 2024;233:692–702.
69.
Doi K, MacMahon H, Katsuragawa S, Nishikawa RM, Jiang Y. Computer-aided diagnosis in radiology: potential and pitfalls. European Journal of Radiology. 1999;31(2):97–109.
70.
Baaske A, Brotto LA, Galea LAM, Albert AY, Smith L, Kaida A, et al. Barriers To Accessing Contraception and Cervical and Breast Cancer Screening During COVID-19: A Prospective Cohort Study. Journal of Obstetrics and Gynaecology Canada. 2022;44(10):1076–83.
71.
Belchior R, Somogyvari P, Pfannschmidt J, Vasconcelos A, Correia M. Hephaestus: Modeling, Analysis, and Performance Evaluation of Cross-Chain Transactions. IEEE Transactions on Reliability. 2024;73(2):1132–46.
72.
Chen C, Wu Y, Dai Q, Zhou HY, Xu M, Yang S, et al. A Survey on Graph Neural Networks and Graph Transformers in Computer Vision: A Task-Oriented Perspective. IEEE Transactions on Pattern Analysis and Machine Intelligence. 2024;46(12):10297–318.
73.
Davenport T, Kalakota R. The potential for artificial intelligence in healthcare. Future Healthcare Journal. 2019;6(2):94–8.

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